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This is not an anatomical barrier as such, rather a combination of the tight junctions between endothelial cells of brain capillaries and the close association of glial cells with the outside of the capillaries. This arrangement makes diffusion of lipid-soluble drugs into the brain difficult and diffusion of water-soluble drugs almost impossible.
05.02.2020
Wilhelm
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Clearly, the use of independent prescribing will be limited to where the clinical demand exists and this case needs to be fully explored.
31.05.2019
Martin
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