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Figure shows the use of iopamidol to visualize the capsular lining of a lesser metatarsophalangeal joint of the foot during an investigation of a possible capsular tear. Contrast agents can also be used to enhance computed tomography scans and magnetic resonance imaging. Contrast agent use with CT scans is particularly useful for the diagnosis, staging and follow-up of malignant disease and with MRI for imaging the spinal cord. The digestive tract can be imaged following ingestion of barium sulphate suspended in a gel. The preparation must be taken with plenty of water to avoid it causing intestinal obstruction.

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Prophylactic corticosteroids, for example prednisolone, are recommended as premedication hours prior to imaging in such high-risk patients. Contrast agents should also be used with caution in patients with epilepsy because they can provoke seizures; in hepato-renal syndrome (renal failure following liver cirrhosis and jaundice); in severe respiratory disease, especially asthma; and in diabetes. Iodine contrast agents interact with metformin, an oral hypoglycaemic drug used to treat type patient developing lactic acidosis with metformin, particularly if their kidney function is impaired. Metformin has to be stopped prior to radiological examination and should not be restarted until normal renal function has resumed.

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These approaches are still very much in the experimental stages. Epilepsy affects approximately The main symptoms are seizures, often together with convulsions, but there are many types of epilepsy.

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