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- Most drugs cross the placenta to some extent and should be avoided during pregnancy.
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- Its mode of action is not known.
- These bind bile acids in the intestine, increasing their excretion by preventing enterohepatic recycling.
- There are three other groups of drugs licensed in the United Kingdom for the treatment of NIDDM.
- In addition, drugs that reduce the availability of monoamines cause symptoms of depression.
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They may be formulated in this way because the active drug is difficult to administer, whereas the inactive prodrug does not cause the same complications, or because the active drug is not absorbed or distributed to its intended site of action easily. Most tissues in the body have the enzymes capable of metabolizing a variety of substances.
Gabapentin is used in partial epilepsy together with other drugs that have failed to provide control alone. Adverse effects of gabapentin are gastrointestinal disturbances, mild sedation and ataxia. Topiramate is a recently developed anticonvulsant with similar actions to phenytoin. It appears to block sodium ion channels and enhances the action of GABA. Topiramate is used, either alone or in addition, when other drugs do not provide adequate control.
Amiodarone is used to treat arrhythmia. This drug prolongs the refractory period in cardiac muscle without affecting the rate of depolarization. This means that the interval required for re-excitation is prolonged and arrhythmias are suppressed. Amiodarone is effective in both atrial and ventricular arrhythmias. Adverse effects include photosensitivity and skin reactions and the rare but more serious risk of pulmonary fibrosis.
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Diabetes mellitus is a chronic metabolic disorder caused by deficiency of insulin. Hyperglycaemia results because cells are unable to take up and use glucose.
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