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Common side effects include headache, muscle pain, flushed skin, and nausea. Tadalafil was approved for medical use in the United States in Tadalafil is used to treat erectile dysfunction ED, benign prostatic hyperplasia BPH, and pulmonary arterial hypertension. The pulmonary vascular lumen is decreased in PAH as a result of vasoconstriction and vascular remodeling, resulting in increased pulmonary artery pressure and pulmonary vascular resistance. Tadalafil causes pulmonary artery vasodilation, and inhibits vascular remodeling, thus lowering pulmonary arterial pressure and resistance.

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