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This is a rapid event, occurring in milliseconds, which indicates that the receptor is directly connected to the channel. These are receptors for many hormones and neurotransmitters and are coupled to effector systems by a G-protein. The β-adrenoreceptor was the first of this type to be characterized and others seem to be similar. The structure is a single polypeptide chain spanning the membrane, folded into seven transmembrane domains and coupled to a G-protein. G-proteins are found on the inside of the membrane and act as transducers between receptors and cellular effectors. They are made up of three subunits one of which activity.
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It is thought that there is an abnormality of dopamine receptors or increased release of dopamine in the mesolimbic and mesocortical pathways in schizophrenics.
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Benedikt
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The dose of levodopa can be reduced and there is evidence that this combination has a neuroprotective effect and slows the progression of the disease. This may be because in Parkinsons disease, MAO-B is involved in the production of an endogenous neurotoxin.
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Some drugs, for example phenytoin, oral contraceptives and isoniazid, can cause reduced absorption of folic acid.
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Myasthenia gravis is an autoimmune disease where acetylcholine receptors at the neuromuscular junction are progressively destroyed.
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What can you deduce about Mrs Singletons condition from the multiple use of inhalers and occasional prescription of oral corticosteroids and antibiotics. Given Mrs Singletons aversion to taking steroids, what could you say about their use to reassure her.
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