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A mixture of soluble (rapid and short duration of action) and isophane human insulin twice a day is the most commonly used regime. However, since the duration of action of insulin preparations varies from patient to patient, combinations of different preparations have to be determined for individual patients. The aim of insulin therapy is to achieve the best possible control of blood glucose concentration, without precipitating hypoglycaemic episodes, to avoid complications. Insulin is ineffective orally and has to be administered by injection. The usual route is subcutaneously, though the soluble rapid-acting preparations can be given intravenously in emergencies.

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