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It is generally acknowledged that treatment of bereavement with antianxiety drugs is not appropriate. Grieving is a natural process that serves a purpose in recovery from loss. It is important to realize that some medical conditions can mimic the symptoms of generalized anxiety disorder, for example hyper- or hypothyroidism, hypoglycaemia, drug or alcohol withdrawal and cardiac arrhythmias. Anxiety and fear are both associated with general arousal of the CNS and may be due to over activity in the RAS. Neurotransmitters in the RAS are serotonin and GABA.

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In addition, giving alone or in combination with chlorimipramine seems to benefit these patients. Evidence against this serotonin theory includes the fact that low levels of ( have recovered and in some patients with mania. It seems likely that low levels of serotonin or noradrenaline do not cause depression, but that more complicated mechanisms involving a change in balance between these monoamines are involved.

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