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At equilibrium, drugs are partitioned between plasma, plasma proteins and the different tissues. The rate of distribution to different tissues depends largely on the rate of blood flow through them.
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Diuretics may also increase plasma lipid levels and cause glucose intolerance and insulin resistance, so they have to be used with caution in individuals with hyperlipidaemia andor diabetes. In addition, most diuretics produce an increase in plasma uric acid levels, which may lead to gout.
12.10.2020
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Loss of drugs in sweat and breast milk occurs, but is of minor importance although the appearance of drugs in breast milk can have serious consequences for the nursing baby. Drugs can be administered to patients by a variety of routes and can be intended to have a local or systemic effect.
18.12.2018
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Adverse effects include photosensitivity and skin reactions and the rare but more serious risk of pulmonary fibrosis.
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When a nerve impulse arrives at a synapse, chemical substances are released.
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As the drug concentration increases, depression of the medulla results in breathing becoming rapid and shallow.
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