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Chloroquine inhibits digestion of haemoglobin by the parasite and both drugs inhibit the disposal of haem, which is toxic to the parasite. falciparum is resistant to chloroquine in most parts of the world.
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Disadvantages are that many drugs do not taste particularly nice; some can upset the stomach and cause nausea and vomiting or even ulcerate the stomach lining, while others may be destroyed by stomach acid or digestive enzymes or be extensively metabolized in the liver. The oral route requires a co-operative and conscious patient.
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The local anaesthetic is introduced into the extradural space between the bone of the spine and the dura mater, which is filled with fatty tissue and blood vessels.
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The metabolism of many drugs is directly proportional to the rate of blood flow through the liver; that is they exhibit flow-dependent hepatic clearance.
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