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The symptoms are systemic oedema, particularly of the legs and ankles. Biventricular failure often follows left ventricular failure and consequently oedema develops in the peripheral tissues, causing swelling of the legs, and in the lungs, causing breathlessness. There are no drugs to cure cardiac failure but the condition can be controlled by drug therapy. Drug groups used to control cardiac failure are cardiac glycosides, diuretics, ACE inhibitors and angiotensin II receptor antagonists. Ischaemic heart disease arises if one or more of the coronary arteries become partially occluded. This leads to reduction in blood flow to the myocardium.

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Aqueous compartments include tissue fluid, cellular fluid, blood plasma and fluid in places like the central nervous system, the lymphatic system, joints and the gastrointestinal tract. The distribution of a drug into these different compartments depends on many factors. Aqueous solubility affects distribution because water-soluble drugs have difficulty crossing cell membranes and therefore tend to remain in the circulation. Consequently, water-soluble drugs are not well distributed throughout the body. They exist in large amounts in the plasma or tissue fluid and are rapidly cleared by the liver or kidney. In practice, such drugs have little therapeutic use.

Angina may be categorized as stable or unstable. Stable angina is a condition that is predictable and results from exertion or stress. Symptoms recede when the stress or exertion ceases. This type of angina is usually due to severe chronic coronary artery disease. Unstable angina is often unpredictable and occurs at rest or because of minor exertion. The underlying pathology is thrombus formation or extension in the coronary arteries.

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