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The psychopharmacology of alcohol dependence is today poised at interesting crossroads. While Naltrexone may reduce craving, Acamprosate scores on cost effectiveness worldwide with Disulfiram being an alcohol deterrent drug. Combining one or more of them is also a trend seen. The most important factor in efficacy has been the combination of psychosocial treatment with medication. Alcohol dependence is a major mental health problem in India. This is a little lower than the three to five per cent estimate for major world populations Murray and Lopez, ; Makela, Martikainen and Nihtila, Today, with a better understanding of the basic neurobiological components of alcohol dependence, we have pharmacological agents targeted at improving drinking behavior, enhancing abstinence and preventing relapse as well as reducing the amount of alcohol people drink when they relapse Swift, ; Rosenthal, There are currently three US FDA approved medications for the relapse prevention of alcohol dependence.

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