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This will increase the pharmacological activity of both drugs, but the action of warfarin is of most importance. Drug interaction is not always an adverse reaction. In hypertension, for example, the additive effects of multiple drug therapy is often necessary to achieve a reduction in blood pressure. Type B adverse drug reactions are much rarer than type A, but they are unpredictable and not dose-related and they are potentially more serious. Many are due to drug allergy, but there are other causes.

They are part of the immune system and help protect the skin from microbial infection. Hair follicles, sebaceous glands and sweat glands are part of the epidermis, but they penetrate into the dermis. The dermis consists of loose connective tissue containing fibroblasts that produce collagen and elastic fibres. The dermis also contains lymphocytes, mast cells and macrophages, which respond to injury, infection, allergens and harmful chemicals by releasing inflammatory substances. The dermis has a good blood supply and variation in blood flow through the dermis and the production of sweat are important in body temperature control.

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