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Local anaesthetics cause varying degrees of vasodilation. The combination of a fall in heart rate and peripheral vasodilatation can result in a fall in blood pressure and fainting. Interactions of local anaesthetics with other drugs are relatively rare and are most likely to occur if both drugs are given intravenously.

Phencyclidine was developed in the hallucinations and delirium. It became popular as PCP, a drug of abuse, in the Ketamine has limited use for induction of anaesthesia in children. Adverse effects of ketamine are that it causes muscle twitching and excessive salivation together with nightmares and hallucinations. Premedication is used to prepare the patient for general anaesthesia. The objective is to reduce feelings of anxiety and lightly sedate the patient.

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If this generic does not suit you, do not hesitate to ask your pharmacist for another. How do you explain it? Keep this leaflet. Do not give this to anyone else. It could harm them, even if the signs of their illness are the same as yours. If you get any side effects, talk to your doctor, pharmacist or nurse. This also applies to any side effect that is not mentioned in this leaflet. See section 4.

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And how might you predict if a patient is likely to have an allergic reaction to a particular drug. are likely to be altered in older people.

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) Use of iodine contrast agents is contraindicated in pregnancy because they can cross the placenta and interfere with foetal thyroid development. Special precautions should be taken in patients with known hypersensitivity to iodine and in those with other allergies, for example to foods or other drugs.

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Although drug allergy is unpredictable, it is more likely to occur in individuals with a history of atopic disease, for example asthma. The allergen, whether it is a drug, pollen or dust mite, causes production of immunoglobulin E antibodies on first exposure. These antibodies attach themselves to mast cells.

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This in turn reduces peripheral vascular resistance and they are used to reduce blood pressure. Examples are amlodipine and nifedipine. Nifedipine also has a use in the treatment of Raynauds disease. In Raynauds disease, there is inappropriate vasoconstriction in the fingers and toes, usually in response to cold.

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