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The cannabinoid CB system is a rational novel target for treating opioid dependence, a significant public health problem around the world. Observer-rated measures
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The cannabinoid CB system is a rational novel target for treating opioid dependence, a significant public health problem around the world. This proof-of-concept study examined the potential efficacy of a CB 1 receptor partial agonist, dronabinol, in relieving signs and symptoms of opioid withdrawal. Twelve opioid dependent adults participated in this 5-week, inpatient, double-blind, randomized, placebo-controlled study. Placebo was substituted for oxycodone maintenance doses for 21 hours before each session in order to produce measurable opioid withdrawal. Oxycodone produced prototypic opioid agonist effects i. In, there were 2. Given the chronic relapsing nature of opioid dependence McLellan et al.
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Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in Oxycodone is indicated for the treatment of moderate to severe pain. These tissues include the respiratory centre in the brain stem, the cough centre in the medulla, muscles of the pupils, by ambien online tract, cardiovascular system, endocrine system, and immune system. Label Oxycodone's effect on the respiratory centre is dose dependant respiratory depression. Label The action on the cough centre is suppression of the cough reflex.
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