The idea of a special meeting dedicated to the Future of Europe during the Romanian Presidency was first floated by the Commission, whose president suggested that it should take place on or immediately after Brexit Day on 29 March. It was gesture politics of the kind which the self-styled Last Chance Commission has indulged in too frequently for comfort since and was rapidly dismissed as over the top. Which says an awful lot about both the process and the mood in which those who attend the meeting will approach their task. These, it might be said, are the real world issues which the heads of state and government ought to be talking about. Not Brexit. The present note is a narrative in the proper sense of the term: an attempt to give meaning to a process by describing and analysing step by step what actually happened.

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Drugs used to treat these disorders often interact with neurotransmitters or receptors. However, the full explanation of how the drugs work is still unknown and it can take many weeks for them to have an effect. Unipolar depression is associated with a decrease in noradrenaline andor serotonin activity and drugs effective in its treatment increase the concentration of one or both these transmitters at their synapses. Bipolar depression is associated with a decrease in dopamine activity and mania with an increase in dopamine activity. Both these conditions can be treated prophylactically with lithium, although the mode of action of lithium is unknown.

The neurotransmitter of this pathway is dopamine and loss of dopamine-containing neurons here causes Parkinsons disease. The hypothalamic-pituitary dopamine pathway inhibits the release of prolactin from the anterior pituitary gland. The mesolimbic and mesocortical pathways are dopamine-containing neurones that run from an area in the midbrain called the ventral tegmentum to the limbic system and the prefrontal area of the cerebral cortex respectively. These are areas of the brain that are normally involved in behavioural and emotional functions. In addition, the chemotrigger zone of the medulla contains dopamine-containing neurones that initiate vomiting in response to noxious and possibly toxic substances. It is thought that there is an abnormality of dopamine receptors or increased release of dopamine in the mesolimbic and mesocortical pathways in schizophrenics.

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