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In diseases that primarily affect the joints there is inflammation and proliferation of cells of the synovial membrane and damage to cartilage and bone, but other connective tissues and organs in the body can also be damaged. Rheumatoid arthritis is a chronic inflammatory autoimmune disease of largely unknown aetiology affecting about than men.

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Pharmacology as a science encompasses the following: the action of natural chemicals in the body; the origins and sources of drugs; their chemical structure and physical characteristics; their mechanisms of action; their metabolism and excretion; studies of their action on whole animals, isolated organs, tissues and cells, enzymes, DNA and other components of cells; ultimately studies of their actions in humans and their therapeutic uses.

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