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Diseases of the liver and kidney, any disease that affects intestinal motility, mal-absorption syndromes and any condition that reduces plasma protein concentration are all implicated. Some diseases can alter the physiological sensitivity to a drug at its site of action.

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This group of anti-psychotic drugs has a similar mode of action and side effects to the phenothiazines. Butyrophenones are of particular use for the rapid control of hyperactive states and in older people because they are less likely to cause a drop in blood pressure.

Lewy bodies are intra-neuronal inclusions and can be found throughout the brain and cerebral cortex. There appear to be three types of Lewy body disease: brain stem predominant and neocortical (associated with dementia). Cigarette smokers appear to be at a reduced risk of developing Parkinsons disease. The reasons for this are not know, but suggestions include nicotine induction of detoxifying enzymes, inhibition of harmful enzymes or stimulation of factors that protect neurons. Treatment of Parkinsons disease is not usually started until symptoms are interfering with daily life and should be initiated under supervision of a specialist. The aim of drug therapy is to slow progression of the disease, but there is no cure.

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Qualified, registered podiatrists are allowed to access and administer lidocaine, bupivacaine, prilocaine, mepivacaine, levobupivacaine and ropivacaine. Analgesia can be achieved by peripherally acting and centrally acting analgesics. The most commonly used peripherally acting analgesics are paracetamol and aspirin for mild to moderate pain. For moderate to severe pain morphine is commonly used. Peripherally acting analgesics work by inhibiting the enzyme necessary for prostaglandin synthesis.


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Antibiotics used to treat respiratory infections in cystic fibrosis commonly include ciprofloxacin, erythromycin, flucloxacillin and amoxicillin. However, specialist individual therapy is essential for maximum benefit to the patient and avoidance of the development of resistant strains of bacteria.

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