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29.02.2020
Thomas
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After this the cycle repeats itself.
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The drugs should be used at the maximum dose that can be tolerated and as frequently as possible to discourage tumour regrowth. Mechanisms of acquired resistance to cancer chemotherapy include: decreased uptake of drug into cells, or increased expulsion from cells; increased production of substances that can inactivate the drug; increased activity of DNA repair enzymes; increased metabolism and inactivation of the drug; reduced conversion of drug into its active form.
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Typical symptoms of anaemia are fatigue due to anoxia and intolerance to cold and paleness due to low levels of haemoglobin.
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The effects of this can be local, for example hay fever, asthma and urticaria, or systemic causing whole body oedema and anaphylactic shock.
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