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These notes of between 15, and 30, words apiece appear weeks after each meeting of the heads of state and government and provide a comprehensive analysis of the discussion and its outcome. Based on oral and documentary sources which are not normally available, they provide a unique and authoritative insight into decision-making at the heart of the EU. Once his successor is in place, he will turn his attention to editing the archive volumes of his work and writing a monograph on the history of the European Council. Preliminary evaluations 6 to 9 per annum depending on number of meetings These notes of between 15, and 30, words apiece appear weeks after each meeting of the heads of state and government and provide a comprehensive analysis of the discussion and its outcome. Like no-one else he understands the mechanisms. An invaluable source.

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It is not clear exactly how dithranol exerts its action but it appears to interact with DNA and directly inhibit cell proliferation. Dithranol can cause inflammation, so initially concentrations no greater than should be applied for off. If this is tolerated, higher concentrations can be used to provide optimum response. Since dithranol irritates normal skin, it should not be used in flexures, on the face or in skin folds. Coal tar preparations are complex and variable mixtures of hydrocarbons that have cytostatic or antimitotic actions. Crude coal tar is the most effective, but few outpatients tolerate the mess and smell.

Acute side effects of PUVA treatment are nausea from the psoralen and blistering and erythema from the UVA. UVA is principally responsible for photo-ageing and penetrates tissues far more deeply than UVB. Long-term risks of PUVA include accelerated skin ageing and an increased incidence of skin cancer. Patients must not be taking other photosensitizing drugs, for example phenothiazines and benzodiazepines, NSAIDs and some antibiotics. Psoralens are naturally occurring plant extracts found in the parsnip family and the technique has a long history, being used by Egyptians and Indians to treat vitiligo as long ago as in the skin and photochemotherapy is still used to treat it. Psoralen causes stimulation of melanocytes and some repigmentation in vitiligo.

Stimulant laxatives work by stimulating enteric nerves, which results in smooth muscle contraction and an increase in peristalsis. At the same time they increase fluid secretion from the intestinal mucosa. Stimulant laxatives can cause abdominal cramps. Stimulant laxatives are unsuitable for prolonged use because this can lead to excessive loss of potassium ions and a colon that no longer responds to stimulation. They are, however, useful for emptying the bowel before surgery and radiological imaging.

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