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- Phenobarbital is very similar to phenytoin in use and not effective in absence seizures.
- Its mode of action appears to be by blocking sodium ion channels.
- It seems likely that low levels of serotonin or noradrenaline do not cause depression, but that more complicated mechanisms involving a change in balance between these monoamines are involved.
- Resistance to antimalarial drugs is common.
- After much consultation with the medical, pharmacy and nursing professions and the Department of Health and the Medicines Control Agency as well as meetings of the Committee on Safety of Medicines and the Medicines Commission, amendments were made to the legislation to allow nurses and pharmacists to become supplementary prescribers as from April A similar process occurred with the podiatry, physiotherapy and radiography professions and led to changes to the NHS Regulations in April prescribing to these professions.
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It tends to accumulate inside neurons and may interfere with nerve action potentials or the activation of second messenger systems within the neuron. In addition, lithium may inhibit the release of monoamines from nerve endings and increase their uptake.
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