Isotretinoin belongs to the drug class retinoids. This medication is used to treat severe cystic acne nodular acne. Isotretinoin is preferred medicine for cystic acne if it has not responded to medications like clindamycin, tetracycline or minocycline. Dryness of mucous membranes, dryness of skin with scaling, fragility, erythema, cheilitis, pruritus, epistaxis, conjunctivitis, dry sore mouth and palmo-plantar exfoliation. Corneal opacities, dry eyes, visual disturbances, skeletal hyperostosis and musculoskeletal symptoms. Hair thinning, photosensitivity, changes in skin pigmentation, paronychia. GI disturbances, hepatitis.

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Despite advances in acne therapy in recent years, treatment failure is common. The aim of this study was to investigate the efficacy of low daily dose isotretinoin in moderate to severe acne patients. The secondary objective was to measure the rate of relapse 5 years after the completion of therapy. In this retrospective, noncomparative study, patients with moderate to severe scare prone acne. Liver function tests serum glutamic-oxalocetic transaminase, serum glutamate pyruvate transaminase, direct and total bilirubin, and lipid profiles total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride were evaluated for all patients, before the initiation of treatment and again after the 2 nd month of treatment. At the end of treatment course, All adverse effects were mild, and discontinuation of treatment was not necessary. Low dose isotretinoin was found to be a safe and effective choice for patients with moderate to severe scar prone acne vulgaris. Acne is a very common skin disease in young people, aged years old, but it can occur in whole life. Isotretinoin has been used more commonly in recent years, especially for treatment of nodular and nodulocystic acne.

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Accutane inhibits the production of sebum and reduces the size of the gums with the main active substance isotretinoin. It is proved that isotretinoin has an antiseptic effect. Also, isotretinoin thinens the stratum corneum of the epidermis to more easily penetrate deep into the affected area. Due to the fact that Accutane suppresses the sebum secretion by reducing the sebaceous glands themselves, this allows to reduce the migration of bacteria in the ducts. And due to the fact that the stratum corneum is thin, the skin fat has an outlet to the outside, from which there is no blockage of the pores and, as a result, pimples.

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Isotretinoin in just a single dose can cause severe birth defects or death of a baby. Never use isotretinoin if you are pregnant or may become pregnant. You must have a negative pregnancy isotretinoin 20 mg price before taking isotretinoin. Isotretinoin can cause miscarriage, premature birth, severe birth defects, or death of a baby if the mother takes this medicine at the time of conception or during pregnancy. Even one dose of isotretinoin can cause major birth defects of the baby's ears, eyes, face, skull, heart, and brain.

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Sympathomimetic drugs such as xylometazoline can be used as decongestants. Antihistamines are used in the treatment of allergic rhinitis and hay fever. They reduce symptoms such as runny nose and sneezing, but are less effective for nasal congestion. There are many antihistamines available and they differ in their duration of action, anticholinergic effects and incidence of drowsiness. Older antihistamines are the most likely to cause drowsiness. Newer ones, for example acrivastine, are preferred because they penetrate the blood-brain barrier less easily and cause less sedation.

Evidence against this isotretinoin 20 mg price theory includes the fact that low levels of ( have recovered and in some patients with mania. It seems likely that low levels of serotonin or noradrenaline do not cause depression, but that more complicated mechanisms involving a change in balance between these monoamines are involved. Despite evidence for and against, there remains one major problem with the monoamine theory of depression. All antidepressants take weeks to have an effect, which is far longer than it takes to alter brain amines. It has been suggested that effects of antidepressants are due to adaptive changes in the brain, which may involve down regulation of receptors or some other change in their sensitivity. Some of the newer types of antidepressants do not facilitate monoamine transmission at all.

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