Isotretinoin in just a single dose can cause severe birth defects or death of a baby. Never use this medicine if you are pregnant or may become pregnant. You must have a negative pregnancy test before taking isotretinoin. Isotretinoin can cause miscarriage, premature birth, severe birth defects, or death of a baby if the mother takes this medicine at the time of conception or during pregnancy. Even one dose of isotretinoin can cause major birth defects of the baby's ears, eyes, face, skull, heart, and brain. Never use isotretinoin if you are pregnant.

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This treatment is usually prescribed as a last resort when other medications have been tried and failed to provide relief. Accutane should be taken with a glass of water and must be swallowed, not chewed. Short term side effects include an apparent worsening of acne. However this is only temporary as the body is getting used to the medication. After a few days or weeks acne will be begin to clear up. Some patients have also experienced changes in their blood pressure so regular checkups is necessary.

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