Despite advances in acne therapy in recent years, treatment failure is common. The aim of this study was to investigate the efficacy of low daily dose isotretinoin in moderate to severe acne patients. The secondary objective was to measure the rate of relapse 5 years after the completion of therapy. In this retrospective, noncomparative study, patients with moderate to severe scare prone acne. Liver function tests serum glutamic-oxalocetic transaminase, serum glutamate pyruvate transaminase, direct and total bilirubin, and lipid profiles total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride were evaluated for all patients, before the initiation of treatment and again after the 2 nd month of treatment. At the end of treatment course, All adverse effects were mild, and discontinuation of treatment was not necessary.

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I have been on 30 mg of accutane a day for 90 days 3 months and the only real side effects are a bit of dry skin around the mouth and of course the damn lips. Nothing bad. I tolerate accutane very well. If I get a bit more dry skin I don't care and I am willing to make that sacrifice to finish quicker. Or should I stay on 30mg for 10 months? I am 60kg, 24yrs, 5' While it's understandable why you want to finish earlier, remember that the higher the dosage the more inclined you will be to have worse side effects dryness, nosebleeds, etc. Many people try to do this and hate the side effects so much they end up not actually finishing the course out by going back to the lower dosage again, but just stopping overall.

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It may be prescribed for other uses, including other skin problems and certain kinds of cancer. This drug is a vitamin A derivative retinoid, so your body reacts to it in a similar way that it does to vitamin A. Because vitamin A can build up in your tissues, it can quickly become a problem. It can do a good job of clearing up your skin, but there are some potential side effects. Most of these fade within a few weeks after you stop taking it. The dose is tailored to each person, and treatment usually lasts four to five months.

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New evidence is increasingly suggesting that isotretinoin may be best prescribed using a lower daily dose, with the regimen tailored to the individual patient, the severity of their acne and their response to the medicine. There are several problems with prescribing isotretinoin based on a high daily dose to reach a cumulative total amount, including: 3. It is likely that the higher dose group represents traditional weight-based prescribing. The current total average daily dose of isotretinoin is 42 mg. Adverse effects of isotretinoin are dose dependent and become more common, and more severe, with higher doses. The duration of treatment with isotretinoin is currently based on the calculated cumulative dose.

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A lower dose 0. However, the benefit of prolonged remission is not as great with such therapy as with standard doses. Some patients only require one course of oral isotretinoin for complete acne remission, while others require additional courses of isotretinoin therapy. Acne vulgaris. The familial risk of adult acne: a comparison between first-degree relatives of affected and unaffected individuals. The psychological and emotional impact of acne and the effect of treatment with isotretinoin.

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For example, the use of amorolfine cream in the treatment of fungal skin infections. Most drugs are not easily absorbed through the skin but some are formulated into dermal patches for systemic absorption and others may penetrate damaged skin. For example, dermal patches can be used to administer nicotine replacement therapy. Other routes of topical administration include application of drugs to the conjunctiva of the eye, the external ear, the vagina and the urethra, usually to treat local infection. Many drugs are given by inhalation and may be intended to have a local or systemic effect.

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