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Authored by Tony Buoncristiani, MD, FAAOS


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These mediators include histamine and prostaglandins together with a range of other substances in small quantities (for example leukotrienes).

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If warfarin and aspirin are used simultaneously, both drugs appear in the plasma in higher than expected concentrations due to competition for plasma protein binding.

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The phases of a cardiac action potential are shown in Figure change in resting membrane potential of cardiac muscle cells from This is due to influx of sodium ions followed by influx of calcium ions. Contraction of the myocardium follows depolarization.

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