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Addition of water. Enzymes capable of catalysing hydrolysis are found in many body tissues but particularly in the small intestine. Phase substances by conjugation with endogenous compounds in the liver. This too encourages renal excretion. The most important conjugation reaction is with glucuronic acid to form a glucuronide.
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Once absorbed into the blood stream, a drug is distributed around the body. From the gastrointestinal tract, a drug goes to the liver in the hepatic portal system where it is likely to be metabolized. Metabolism usually makes a drug more water soluble and less pharmacologically active. Distribution to the rest of the body depends on how well a drug can pass across cell membranes.
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Although drugs do appear in faeces, expired air, sweat and breast milk, these are normally minor routes of excretion.
03.09.2016
Sebastian
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Immunosuppressants such as azathioprine are used when other forms of treatment fail to control the progression of myasthenia gravis.
07.05.2020
Heinrich
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The mechanisms involved in enzyme induction are unclear but somehow DNA sequences are affected so that production of the relevant enzyme is increased. Examples of drugs that are well known to cause enzyme induction are carbamazepine, phenytoin and alcohol.
08.01.2021
Kriemhild
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Side effects of topical use of acyclovir are transient stinging or burning of the skin.
23.07.2019
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