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Adverse effects of mercaptopurine are similar to methotrexate. Mercaptopurine is metabolized by xanthine oxidase. It should be used with caution in combination with allopurinol because allopurinol inhibits xanthine oxidase. Both methotrexate and mercaptopurine are used to treat acute leukaemia. Fluorouracil is a pyrimidine analogue that substitutes for uracil in the synthesis pathway for thymidylate, a necessary step in the synthesis of DNA. Formation of a false nucleotide inhibits an enzyme necessary for DNA synthesis.


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Many of the hormones of the anterior pituitary gland in turn regulate the activity of other endocrine glands and are known as trophic hormones or trophins.

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Tonicclonic seizures are major convulsions involving spasm of all muscles. There is loss of consciousness and possibly incontinence.

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