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  • These questions are answered below.
  • Flucloxacillin is not affected by penicillinase and is used for staphylococcus infection.
  • Non-drug interventions such as weight reduction, increased exercise, salt restriction, stopping smoking, reduction of alcohol intake should always be included in the management of hypertension.
  • Their mode of action is complicated by the fact that currently seven serotonin receptor sub-types are recognized, further into is significance of the the brain and most is known about are inhibitory autoreceptors.
  • Correct use of drugs is paramount.
  • (Probenecid is used to treat gout because it also inhibits the reabsorption of uric acid by a similar mechanism.
  • Cancer cells may travel to distant sites in the body via the blood and lymph to form secondary tumours that are called metastases.

You should be able to answer the following questions using the material in this chapter. This chapter describes some disorders of the central nervous system and the drugs used to treat these conditions.

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There are many antibiotics available, but they fall into three major groups based on their mode of action: inhibitors of bacterial nucleic acid synthesis; inhibitors of cell wall synthesis; and inhibition of bacterial protein synthesis. Resistance of bacteria to commonly-used antibiotics has become a major problem necessitating the development of new antibiotics.

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The effects of inhibition can appear as soon as the inhibiting drug reaches a high enough concentration to compete with another drug for the same enzymes. Cimetidine, a drug used to treat stomach ulcers, can inhibit the metabolism of several potentially toxic drugs such as phenytoin and theophylline. Erythromycin, an antibiotic, similarly increases the activity of theophylline, warfarin and digoxin. Response to drugs varies between individuals and although the reasons are often multifactorial there are cases where gene polymorphism is responsible. There are some well-known examples of individual variation in response to drugs.


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