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This drug interacts with the acetylcholine receptor at the neuromuscular junction, initially stimulating it and then preventing further stimulation by endogenous acetylcholine, resulting in paralysis. Suxamethonium is metabolized at its site of action by the enzyme pseudocholinesterase. The effect of suxamethonium is not reversed by the use of anticholinesterase drugs, but would be prolonged. Side effects of suxamethonium are bradycardia and, rarely, malignant hyperthermia. Individuals with genetically determined less active plasma pseudocholinesterase levels are likely to experience prolonged paralysis with suxamethonium. Opioid analgesics can be used at induction to relieve anxiety and during an operation to control pain buy valium prescription to reduce the need for post-operative analgesia.

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It is due to factors peculiar to the individual that may be genetic in origin, but the mechanisms are usually poorly understood.

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They also reduce the number of some receptors, which may contribute to the therapeutic action, but their complete mechanism of action is unknown. Examples of tricyclic antidepressants include imipramine and amitriptyline (for use of amitriptyline in neuropathic pain.

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