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Agonists are drugs that stimulate receptors and antagonists block the action of the natural chemical at the receptors. There are four main receptor types based on the mechanism by which they exert their effects.

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This could be through potentiation of neurotransmitter release at inhibitory synapses or by inhibition at excitatory synapses. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter and glutamate is an excitatory neurotransmitter in the brain.

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Another example would be the administration of local anaesthetics and anti-inflammatory corticosteroids by intra- and extra-articular injections by physiotherapists involved in the ongoing management of rheumatology patients. Radiographers have been trained since and management of side effects of radiotherapy under PGDs.

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These substances are POM and would otherwise only be available for use by appropriate medical practitioners.

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