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This is a diverse group of drugs, which fall into three classes. They all block influx of calcium ions during depolarization of muscle cells. Class I calcium channel blockers work preferentially on calcium ion channels in cardiac muscle cells.
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PUVA has also been shown to cause alteration in the immune response, which may play a role in reducing inflammation. PUVA treatment is usually reserved for severe, resistant psoriasis, when there is a high success rate, often as high as is seen.
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