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Its significance is that other drugs metabolized by the same enzymes are metabolized faster and therefore circulate in a lower concentration than expected for a given dose. This could mean that they become ineffective. Alternatively, a drug could be metabolized faster than expected into a toxic compound. The mechanisms involved in enzyme induction are unclear but somehow DNA sequences are affected so that production of the relevant enzyme is increased. Examples of drugs that are well known to cause enzyme induction are carbamazepine, phenytoin and alcohol.

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All Trust and university-based training offered to radiographers in this area is normally on a multi-professional basis. There is very little published evidence to indicate how and when PGDs and supplementary prescribing can be used in radiography (Hogg and Hogg, Hogg and Hogg practices have had on radiography patient care and management.

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