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  • Aqueous solubility affects distribution because water-soluble drugs have difficulty crossing cell membranes and therefore tend to remain in the circulation.
  • Piperazine has few side effects, mainly gastrointestinal disturbances.
  • However, there are two main theories to explain the mechanism of action of general anaesthetics.
  • Common adverse effects of oral griseofulvin are diarrhoea, nausea, vomiting, headache and photosensitivity.

Other forms are less severe and rarely fatal. Toxoplasmosis is common in the United Kingdom and in most cases causes a mild influenza-like illness, although infection during pregnancy can be a cause of abortion or neurological damage in the foetus.

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This requires the action of enzymes. New nucleotides pair C cytosine G guanine T thymine A adenine base sugar base phosphate Figure with the existing bases of each strand: adenine nucleotides pair with thymine; guanine nucleotides pair with cytosine.

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A serious side effect or fibrates is a myositis-like syndrome, which is made worse by soma online overnight use of statins. Such a combination is not recommended except in cases of severe familial hyperlipidaemia. Nicotinic acid derivatives reduce the release of VLDLs from the liver and the removal of triglycerides from them in adipose tissue. This results in a fall in circulating LDL levels. An example is acipimox. Because of side effects, use of these drugs is now limited to treatment of familial hyperlipidaemia in combination with bile acid sequestrants.

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Patients are usually given folic acid because there is a high turn over of erythrocytes and they are likely to become deficient in folic acid. In normal lipid metabolism, lipids in the diet are converted to triglycerides, which are used in muscle and adipose tissue.

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