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PThe academic of a drug into these different compartments depends on many years. Aqueous solubility affects distribution because contrast-soluble drugs have difficulty crossing cell membranes and therefore circulate to remain in the circulation. Largely, water-soluble drugs are not well established throughout the body. They exist in large amounts in the urine or tissue fluid and are highly cleared by the concept or kidney. p pIn practice, such combinations have little therapeutic use.

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Contrast agents should also be used with caution in patients with epilepsy because they can provoke seizures; in hepato-renal syndrome (renal failure following liver cirrhosis and jaundice); in severe respiratory disease, especially asthma; and in diabetes. Iodine contrast agents interact with metformin, an oral hypoglycaemic drug used to treat type patient developing lactic acidosis with metformin, particularly if their kidney function is impaired. Metformin has to be stopped prior to where to buy propecia in usa examination and should not be restarted until normal renal function has resumed. of contrast agents With intravenous administration, there is always a risk of damage to veins through mechanical or chemical means. A good cannulation technique is essential to avoid extravasation, tissue damage or the introduction of air into the circulation.

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