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IM aripiprazole substantially reduced agitation within 45 to 60 minutes of dosing in randomized, double-blind, placebo-controlled studies. Whereas other SGAs have relatively little effect on D 2 dopamine receptors and relatively high 5-HT 2A serotonin receptor affinities, aripiprazole appears to work via partial D 2 receptor agonism. |
Inhibits transport of calcium into myocardial and vascular smooth muscle cells, resulting in inhibition of excitation-contraction coupling and subsequent contraction. |
Wolff-Parkinson-White syndrome, Lown-Ganong-Levine syndrome, symptomatic severe hypotension systolic BP IV: Use in newborns because of benzyl alcohol, concomitant beta-blocker therapy, cardiogenic shock, ventricular tachycardia must determine whether origin is supraventricular or ventricular. Mild elevations of transaminases with and without concomitant elevation in alkaline phosphatase and bilirubin observed; elevations were usually resolved even with continued diltiazem treatment. |









