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Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Cilostazol is 6--3,4-dihydro-2 1 H -quinolinone, CAS PLETAL cilostazol tablets for oral administration are available in 50 mg triangular and mg round, white debossed tablets. PLETAL is indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance. The recommended dosage of PLETAL is mg twice daily taken at least half an hour before or two hours after breakfast and dinner.

Blood and lymphatic system disorders: Agranulocytosis, aplastic anemia, granulocytopenia, thrombocytopenia, leukopenia, bleeding tendency. Cardiovascular: Torsades de pointes, QTc prolongation, left ventricular outflow tract obstruction. General: Pain, chest pain, hot flushes, extradural or subdural hematoma, hyperglycemia, hyperuricemia, increased BUN, elevated BP, decreased platelet or white blood cell WBC count. Skin: Subcutaneous hemorrhage, pruritus, skin eruptions such as Stevens-Johnson syndrome, skin drug eruption dermatitis medicamentosa. Avoid use in patients with hemostatic disorders or active pathologic bleeding eg, bleeding peptic ulcer, intracranial bleeding due to reversible platelet aggregation. Response may be seen as early as weeks after initiation, but treatment may be needed for up to 12 weeks. Left ventricular outflow tract obstruction reported in patients with sigmoid shaped interventricular septum; monitor patients for development of new systolic murmur or cardiac symptoms after initiating therapy.

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Intermittent claudication is a condition characterized by narrowing of blood vessels in the legs, which causes leg pain that worsens with walking and improves when resting. The drug is in a class of medicines known as platelet-aggregation inhibitors. Cilostazol contains a black-box warning because similar medications have caused an increased risk of death in people with congestive heart failure. Tell your doctor or dentist you're taking this medication before any type of surgical procedure, and let your healthcare provider know if you've had a recent surgery before starting on cilostazol. In rare instances, this drug can lower your body's ability to fight infection.

Cilostazol Pletal, a quinolinone derivative, has been approved in the U. The vasodilatory and antiplatelet actions of cilostazol are due mainly to the inhibition of phosphodiesterase 3 PDE3 and subsequent elevation of intracellular cAMP levels. Recent preclinical studies have demonstrated that cilostazol also possesses the ability to inhibit adenosine uptake, a property that may distinguish it from other PDE3 inhibitors, such as milrinone. Elevation of interstitial and circulating adenosine levels by cilostazol has been found to potentiate the cAMP-elevating effect of PDE3 inhibition in platelets and smooth muscle, thereby augmenting antiplatelet and vasodilatory effects of the drug. Cilostazol has also been reported to inhibit smooth muscle cell proliferation in vitro and has been demonstrated in a clinical study to favorably alter plasma lipids: to decrease triglyceride and to increase HDL-cholesterol levels.

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The submission sought an Authority Required listing for the symptomatic improvement of intermittent claudication as indicated by increased maximal and pain-free walking distances in patients who do not have rest pain and who do not have evidence of peripheral tissue necrosis. At the July meeting, the PBAC rejected a submission for cilostazol for an authority required listing for the symptomatic improvement of intermittent claudication on the basis of uncertain clinical benefit, uncertain cost-effectiveness and uncertain utilisation estimates. Full details in the July Public Summary Document. Pletal is indicated for the symptomatic improvement of intermittent claudication as indicated by increased maximal and pain-free walking distances in patients who do not have rest pain and who do not have evidence of peripheral tissue necrosis. Intermittent claudication IC is a common debilitating symptom of peripheral arterial obstructive disease.

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The pharmaceutical company has decided to discontinue this product. Healthcare professionals are asked to report any suspected adverse reactions. See section 4. Pletal 50 mg tablets 2. Qualitative and quantitative composition One tablet contains 50 mg of cilostazol.

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Cilostazol is used to treat intermittent claudication. This is a cramping pain that buys pletal cilostazol in the lower leg when you walk and is due to poor circulation. Vasodilators like cilostazol increase the distance you can walk before the pain develops. Cilostazol works in two ways. Cilostazol is prescribed by specialist doctors when it is not possible to improve the symptoms of intermittent claudication by other means.

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Pletal is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate widen. This medicine dilates arteries that supply blood to your legs.

  • The European Medicines Agency's Committee on Medicinal Products for Human Use CHMP has recommended that the use of cilostazol-containing medicines in the treatment of intermittent claudication — a condition where poor blood supply to the leg muscles causes pain and affects the ability to walk — should be restricted with a range of new measures aimed at targeting a patient population in which there are clinical benefits, and at the same time minimising important risks.
  • Over half of all prescribed medications are for generic medications.
  • From: Platelets Second Edition,
  • The pharmaceutical company has decided to discontinue this product.
  • Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia.

Those individuals who are forced to pay for their Pletal and other prescription medications out of pocket may be able to receive relief through Prescription Hope. Those who are prescribed Pletal by doctors may be able to obtain their prescription medications through Prescription Hope.

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By William T. While the mechanism of action of cilostazol in improving intermittent claudication is not precisely known, it is reported to have antiplatelet and vasodilation actions and also demonstrates greater dilation of the femoral arteries than other arteries.

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