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Spasticity is a common symptom in multiple sclerosis. It is defined as an increase in muscle tone characterized by initial resistance to passive movement followed by sudden relaxation. Spasticity can be treated with a number of drugs. Dantrolene has a direct action on skeletal muscle to cause relaxation; baclofen inhibits transmission at the generic pyridium cost cord by acting on inhibitory presynaptic gamma-aminobutyric acid B receptors; benzodiazepines cause muscle relaxation by some central action; and tizanidine is an α action. Side effects of dantrolene, baclofen and tizanidine are similar, being motor incoordination, drowsiness, dizziness, weakness, fatigue and gastrointestinal disturbances.

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It is thought that there is an abnormality of dopamine receptors or increased release of dopamine in the mesolimbic and mesocortical pathways in schizophrenics. However, no reproducible changes in dopaminergic systems have been found in schizophrenia and the abnormality may be in another system that is somehow linked to dopaminergic neurones.

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