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In hypertensive patients over African origin of any age calcium channels blockers or diuretics are now the drugs of first choice. Membrane stabilizers are used to treat arrhythmia. They act directly on sodium ion channels to restrict the entry of sodium ions into cardiac muscle cells. These drugs therefore act to slow the rate of depolarization, which is more marked in ectopic pacemakers, buying cheap aricept 5mg the SA node to regain control of cardiac rhythm. Lidocaine is ineffective orally and its use is restricted to preventing and treating ventricular arrhythmia after myocardial infarction. (Lidocaine by virtue of the same mechanism of action is used as a local anaesthetic.

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This is similar to the mode of action of the antifungal drug, flucytosine. Fluorouracil is used to treat gastrointestinal and breast cancers, often together with synthetic folinates.
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They may be metabolized, but most are excreted unchanged via the kidneys.
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