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John B. Recent reports suggest that existing antihypertensive agents may not have sufficient efficacy to control blood pressure BP in many patients. We compared the efficacy and safety of omapatrilat to a representative angiotensin-converting enzyme ACE inhibitor, enalapril. The Omapatrilat Cardiovascular Treatment vs. Study drug was force-titrated at week 2 and electively titrated at weeks 4 and 6 to a maximum of omapatrilat 80 mg or enalapril 40 mg once daily. Omapatrilat reduced systolic BP 3.
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Chemical stability of enalapril maleate drug substance and tablets by a stability-indicating liquid chromatographic method. The chemical stability of enalapril drug substance and tablets was studied by a stability-indicating liquid chromatographic method. Chromatographic separation was achieved on a RP column, using a mobile phase of methanol phosphate buffer at 1. Degradation of the drug substance was greater under hydrolytic conditions. Keywords: enalapril; stability; liquid chromatography.

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