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Carbamazepine and valproate can be effective in bipolar depression that is unresponsive to lithium and appear to exert their action by depressing the limbic system. Both these drugs are normally used to treat epilepsy, see page is an unlicensed use.

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An example is moclobemide. Nevertheless, MAOIs should be regarded as second line drugs and are indicated when the patient is resistant to other therapy, or is phobic, hysterical or has other atypical symptoms.

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