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Is a single dose of dexamethasone as effective as five days of prednisone for acute exacerbations of asthma? A single dose of mg dexamethasone, which has a longer duration of action than prednisone, is almost as effective as five days of mg prednisone for the prevention of relapse in adults with acute asthma treated in an emergency department. It is a reasonable option for treatment in the emergency department, given its fewer adverse effects. In this study, patients who received the single dose also took placebo for four days. Further research is needed to determine whether patients are comfortable with taking just a single dose. These investigators enrolled adults younger than 56 years who presented with acute asthma to an emergency department and required at least one treatment with a beta agonist.
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White or almost white, round tablets with bevelled edges and scored on one side Thickness: 2. The tablet can be divided into equal doses. Cerebral oedema only with symptoms of intracranial pressure evidenced by computerised tomography caused by a brain tumour, neuro-surgical intervention, cerebral abscess. Initial treatment of extensive, severe, acute, skin diseases responding to glucocorticoids, e. Active phases of systemic vasculitides like panarteritis nodosa treatment duration should be limited to two weeks in cases of concomitant positive hepatitis B serology. Severe progressive course of active rheumatoid arthritis, e. Prophylaxis and treatment of emesis induced by cytostatics, emetogenic chemotherapy within antiemetic treatment. Treatment of symptomatic multiple myeloma, acute lymphoblastic leukemia, Hodgkin's disease and non-Hodgkin's lymphoma in combination with other medicinal products. Dexamethasone is given in usual doses of 0. In more severe disease conditions doses above 10 mg per day may be required.
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Description : Corticosteroid with decadron 8 mg oral glucocorticoid activity but limited mineralocorticoid activity suitable for high dose anti-inflammatory therapy. The initial dose of dexamethasone varies according to use. Bone pain. Liver capsule pain. Nerve compression pain. Obstruction of viscus bowel, bronchus, ureter.
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Dexamethasone, or MK, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Dexamethasone was granted FDA approval on 30 October A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive.

Outpatient treatment of moderate croup with dexamethasone: intramuscular verses oral dosing. Pediatrics ; Moderate croup was defined as hoarseness and barking cough associated with retractions or stridor at rest. Children with mild disease—barky cough only without retractions—or with severe croup—with cyanosis, severe retractions, or altered mental status—were excluded. Other exclusions were reactive airway exacerbation, epiglotitis, pneumonia, upper airway anomalies, immunosupression, recent steroids, or symptoms present for more than 48 hours. Patients were randomized to a single dose of dexamethasone 0.
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Outpatient treatment of moderate croup with dexamethasone: intramuscular versus oral dosing. Exclusion criteria were epiglottitis, foreign body aspiration, reactive airway exacerbation, acute bacterial pneumonia, acquired or congenital upper airway anomaly, immunocompromised status, or steroid exposure during the previous 2 weeks. Both oral and intramuscular dexamethasone were given as a single dose of 0. Main outcome was parent reported need for further treatment after the initial emergency department visit, which could include re-evaluation at a primary care provider's office, additional steroids or racemic epinephrine, or admission to hospital. A secondary outcome was parent reported improvement of symptoms. Children with moderate croup who received oral dosing of dexamethasone did not differ from those who received intramuscular dosing for parent reported need for further treatment after an initial emergency department visit and for parent reported symptom resolution.
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Metrics details. Asthma is a major cause of pediatric morbidity and mortality.
- Initially, 0.
- Drug type: Dexamethasone has many uses in the treatment of cancer.
- Drug type: Dexamethasone has many uses in the treatment of cancer.
- Description : Corticosteroid with potent glucocorticoid activity but limited mineralocorticoid activity suitable for high dose anti-inflammatory therapy.
- Use: For the treatment of cerebral edema.
Cerebral malaria, optic neuritis, active ocular herpes simplex: not recommended. Strongyloides infestation.
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They are used in emergency treatment of severe acute attacks, for the treatment of mild to moderate attacks and prophylactically to prevent attacks. Corticosteroids can be useful in reducing acute exacerbations of chronic bronchitis.
A single neurotransmitter or hormone molecule can activate several G-protein molecules so amplification of effect is achieved. Activation of effector mechanisms results in a product being produced. The product is often a second messenger. Second messengers are intracellular molecules that bring about the effect of the original neurotransmitter or hormone through activation of cellular enzymes. These are receptors for insulin and other growth factors, which are directly linked to tyrosine kinase.

Aspirin taken with warfarin competes for the decadron 8 mg oral protein binding sites, which means that they each displace the other and the amount of free drug in the plasma is increased for both drugs. Patients stabilized on warfarin should never take aspirin because the effect of increased free plasma concentration of warfarin can be severe haemorrhaging. Coincidental increased activity of aspirin is not as serious. Lipid-soluble drugs enter cells readily. Distribution of such drugs is widespread unless plasma protein binding is extensive. Elimination of lipid-soluble drugs is usually slow because clearance from plasma via the kidneys removes only a small proportion of the drug in any given time.
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Halofantrine can also cause cardiac arrhythmia and should be avoided in patients with arrhythmias. These drugs aim to eliminate the resting stage of the parasite in the liver.
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