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Glimepiride belongs to the class of drugs known as sulfonylureas.

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Glimepiride is used to treat high blood sugar levels caused by type 2 diabetes. In type 2 diabetes, insulin produced by the pancreas is not able to get sugar into the cells of the body where it can work properly. Some people can control type 2 diabetes with diet alone or diet and exercise. To work properly, the amount of glimepiride you take must be balanced against the amount and type of food you eat and the amount of exercise you do. If you change your diet, your exercise, or both, you will want to test your blood sugar to find out if it is too low. Your doctor will teach you what to do if this happens.

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Diuretics are used to treat cardiac failure and hypertension. ACE inhibitors and angiotensin II receptor inhibitors limit the action of angiotensin II and suppress aldosterone production. These effects have benefits in the treatment of cardiac failure and hypertension because the resulting vasodilation and water loss lowers blood pressure. Ischaemic heart disease can be treated with nitrates, potassium channel activators, β-blockers and calcium channel blockers. All these drugs either improve the blood supply to the myocardium or reduce its metabolic demand for oxygen, or both. Beta blockers are also useful in treating hypertensive patients who do not respond adequately to other antihypertensive drugs, and some types of arrhythmia because they slow the heart rate.

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Antibiotics for tuberculosis are discussed in Chapter Common respiratory disorders are asthma and chronic bronchitis. Asthma is often, but not always, caused by an allergic response and bronchitis is caused by chronic irritation of the lungs. Both conditions can be treated with inhaled bronchodilators. Although generally asthma responds best to β to antimuscarinic drugs, both types of drugs may be needed. If these do not control symptoms, xanthine bronchodilators may be required in addition to one or both of the other two.


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Glucagon is a hormone normally produced by α-cells of the pancreas in response to low blood glucose levels. Glucagon normally has a hyperglycaemic effect.

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Tolnaftate is not available on prescription, but it can be bought over the counter as a cream. In some patients, it may produce skin reactions such as irritation, puritis or allergic contact dermatitis.

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Combination therapy with two or more drugs may be necessary.

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