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Age-dependent changes in the liver have the most impact on drug metabolism. Over the age of be further reduced by concomitant pathologies such as left ventricular dysfunction or congestive heart failure, both of which are more commonly found in older patients. The metabolism of many drugs is directly proportional to the rate of blood flow through the liver; that is they exhibit flow-dependent hepatic clearance. The size of the liver also reduces with age in both absolute and relative terms. Thus, the number of functioning hepatocytes is reduced, and therefore so is the capacity to metabolize drugs.
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Inhibition of enzyme systems may cause adverse reactions due to higher than expected drug concentrations.
27.09.2020
Moritz
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However, topiramate is teratogenic and should not be used in women of childbearing age. Adverse effects of topiramate are gastrointestinal disturbances, dizziness and drowsiness.
06.07.2017
Katharina
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