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Antiemetic, which is a specific blocker of dopamine D2 and serotonin receptors.

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In a large double-blind study of antiemetic therapy conducted in Italy, patients underwent 3 consecutive cycles of cisplatin chemotherapy. Antiemetic treatment with ondansetron plus dexamethasone was more efficacious and better tolerated, but also more expensive, than price of reglan with metoclopramide plus both dexamethasone and diphenhydramine. To evaluate the different costs of the 2 antiemetic regimens, we conducted a retrospective cost-effectiveness analysis from a hospital perspective. Direct costs of antiemetic therapy acquisition cost of drugs, materials and time spent by nurses to prepare and administer therapies, cleanup after emesis, rescue medication and adverse events were evaluated. Antiemetic drug acquisition costs per patient were 5.

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Inclusive of all Taxes. This medication is a gastrointestinal stimulant and antinauseant, prescribed for heartburn and esophagitis due to GERD and for treating patients who have gastroparesis partial paralysis of the stomach and prevention of nausea and vomiting associated with cancer chemotherapy. Metoclopramide helps the stomach get rid of food and lowers signs of an upset stomach, throwing up, heartburn, and fullness. It is usually taken 4 times a day on an empty stomach, 30 minutes before each meal and at bedtime. Injection is administered by health care providers into the vein. Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly.

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  • Antiemetic, which is a specific blocker of dopamine D2 and serotonin receptors.
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What is metoclopramide, and how does it work? Metoclopramide is a prokinetic drug that stimulates the muscles of the gastrointestinal tract including the muscles of the lower esophageal sphincter, stomach, and small intestine by interacting with receptors for acetylcholine and dopamine on gastrointestinal muscles and nerves. In patients with gastroesophageal reflux disease GERD, a weakened lower esophageal sphincter allows reflux of stomach acid into the esophagus, causing heartburn and damage to the esophagus esophagitis. Metoclopramide decreases the reflux of stomach acid by strengthening the muscle of the lower esophageal sphincter. Metoclopramide also stimulates the muscles of the stomach and thereby hastens emptying of solid and liquid meals from the stomach and into the intestines.


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