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Use should be kept to 12 weeks or less due to risk for tardive dyskinesia. Repeat every 4 to 6 hours as necessary. If required, a mg dose may be used. Dose regimens administered in clinical practice and studies vary and include 0. Repeat doses of 0. In 3 randomized, double-blind, placebo-controlled trials, metoclopramide 0. In each trial, prophylactic administration of ondansetron was more effective than metoclopramide or placebo in controlling postoperative emesis. No adverse effects were reported for metoclopramide in these studies.
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IM: mg administered hours before induction of anesthesia; may be repeated once 30 minutes after initial dose. Lower initial dose and adjust gradually; 2. Restlessness immediate restlessness or agitation may be treated with diphenhydramine 25 mg IV push. Coma, severe CNS depression, concurrent use of large amounts of CNS depressants, poorly controlled seizure disorder, subcortical brain damage. Blood dyscrasias including neutropenia, agranulocytosis, and leukopenia reported with use; discontinue therapy at first sign of blood dyscrasias.

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It also causes suppression of the adrenal cortex. Propofol is the most recently developed intravenous anaesthetic.
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