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Penegra is the generic Sildenafil Citrate tablets.

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Inclusive of all Taxes. This medication is a phosphodiesterase type 5 PDE5 inhibitor, prescribed for erectile dysfunction impotence. It can also be used in pulmonary arterial hypertension. It comes as a tablet to take by mouth and injection to be administered through a vein. To treat pulmonary arterial hypertension it is usually taken three times a day. PO- 50 mg about 1 hour before sexual intercourse. Adjust dose based on response. Max: mgdose and not more than once in 24 hour. Pulmonary Arterial Hypertension- 20 mg 3 times daily. IV- 10 mg

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Sildenafil is used in the treatment of Erectile Dysfunction. Headache, flushing, respiratory tract infection, angina pectoris, AV block, migraine, syncope, tachycardia, postural hypotension, MI, cerebral thrombosis, cardiac arrest, paraesthesia, tremor, depression, herpes simplex, skin ulcer, oesophagitis, abnormal LFT, rectal haemorrhage, hypoglycaemic reaction, arthritis, deafness, retinal vascular disease, photosensitivity, accidental fall. Inhibitors of CYP3A4 such as cimetidine and erythromycin are likely to reduce sildenafil clearance. CYP3A4 inducers such as rifampicin may decrease the plasma concentrations of sildenafil. Plasma concentrations are increased by ritonavir. Potentially Fatal: May potentiate hypotensive effects of of organic nitrates and nicorandil.

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It is measured in milliosmoles per kilogram of water. Cells and body fluids are normally in osmotic equilibrium and have an osmolality of about Addition of ions to them in the form of ionic contrast agents can alter osmolality (the adverse effects, particularly the loss of water from cells, especially blood cells. Other adverse effects are pain on injection, endothelial damage, thrombosis, thrombophlebitis, disturbance of the bloodbrain barrier, bradycardia and increased pulmonary blood pressure. Ionic monomeric contrast agents are known as high osmolar contrast agents and are not much used nowadays because of the risk of adverse effects. Since the are non-ionic contrast agents and therefore do not dissociate in solution.

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