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Authored by Dr. Michelle Lynn Kaplan, MD


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Although results may be complicated by diet, non-brain amines and the inevitable drug therapy, evidence indicates that bipolar depression is associated with a decrease in dopamine activity, mania with an increase in dopamine activity [or depletion of inhibitory gamma-amino butyric acid (GABA)] and unipolar depression with a decrease in noradrenaline or serotonin activity or both.

Levodopa has been shown to produce symptoms of mania in patients with bipolar depression but not in those with unipolar depression.

10.04.2020
Ferdinand Verified

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This could lead to increased incidence of side effects.

20.12.2018
Manfred Verified

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