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Mirtazapine 45 mg tablets are White, biconvex, capsule shaped film coated tablets with '10' debossed on one side and 'A' on the other side.
When you have depression, certain chemicals in the brain are out of their normal balance. Antidepressants such as mirtazapine work by helping to bring the chemicals back into balance. Antidepressants usually take at least a few weeks to achieve their beneficial effect, so it is important to have patience and take the medication exactly as prescribed by your doctor. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do.
I was then diagnosed with anorexia, obsessive compulsive disorder OCD, depression and anxiety. I was prescribed fluoxetine, and to me that was almost THE scariest thing. I knew nothing about this medication at all, or any of my diagnosed conditions. The things I was being told I was feeling and experiencing felt alien and patronising, and I was so terrified of the medication having side effects that it made me ill. My ability to handle my OCD - which had become so difficult to manage that I couldn't go out in public or leave rooms - actually did start to get better, although to this day I'm never sure whether that was influenced by the fluoxetine or by the art therapy I started receiving. My mood plummeted and so did my ability to cope with food. I was put on mirtazapine which made me feel like I was drunk and completely spaced out - and not in a good way.
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Geriatric patients may have reduced clearance of mirtazapine and, as a result, may have increased plasma levels of the drug. In children and young adults, risks must be weighed against the benefits of taking antidepressants. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies. Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy. Akathisia, characterized by subjectively unpleasant or distressing restlessness and need to move, often accompanied by an inability to sit or stand still; most likely to occur within first few weeks; increasing dose may be detrimental. Postmarketing reports of QT prolongation, torsades de pointes, ventricular tachycardia, and sudden death; majority reported in association with overdose or in patients with other risk factors for QT prolongation, including concomitant use of QTc-prolonging medicines. Tetracyclic structure different from SSRIs, TCAs and MAOIs; through its central presynaptic alpha2-adrenergic antagonist effects, stimulates norepinephrine and serotonin release; potent antagonist of 5-HT2 and 5-HT3 serotonin and histamine receptors; is a moderate alpha1 adrenergic and muscarinic antagonist.
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A patient with cardiac disease and diabetic neuropathy is given amitriptyline—a tricyclic antidepressant—to alleviate pain and promote sleep. The patient is still depressed secondary to his clinical condition, however, and so is given paroxetine. Pozuelo said. For antidepressants, the Cleveland Clinic psychiatry consult service favors selective serotonin reuptake inhibitors SSRIs like sertraline Zoloft, citalopram Celexa and escitalopram Lexapro because they have no major drug-drug interactions. The caveat is using the citalopram Celexa in lower dose range of 20 mg or less.
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Common side effects include increased weight, sleepiness, and dizziness. Mirtazapine came into medical use in the United States in Mirtazapine is primarily used for major depressive disorder and other mood disorders. In NICE recommended generic SSRIs as first line choices, as they are equally effective as other antidepressants and have a favourable risk—benefit ratio. However, there is strong evidence that patients taking mirtazapine are less likely to leave treatment early because of side effects, although this is not the case for patients reporting side effects or leaving treatment early for any reason.
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Mirtazapine is most commonly used to treat depression. Remeron SolTabs should be allowed to dissolve in the mouth. No water is needed when taking the SolTabs, since these tablets disintegrate in saliva and are not swallowed whole. Mirtazapine is best known for treating depression. However, it may also be used for treating anxiety or to make people drowsy just before surgery.

Mirtazapine is a newer antidepressant that exhibits both noradrenergic and serotonergic activity. It is at least as effective as the older antidepressants for treating mild to severe depression. Sedation is the most common side effect. Although agranulocytosis is the most serious side effect, it is rare approximately one in 1, and usually reversible when the medication is stopped. Mirtazapine is relatively safe in overdose. Many clinicians consider mirtazapine a second-line or even third-line antidepressant, to be used when older antidepressants are not tolerated or are ineffective.
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Hypersensitivity reactions, usually skin rashes, are quite common while hepatitis, which can be severe and lymph node enlargement are less common.
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