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Duloxetine hydrochloride is used for the acute and maintenance treatment of major depressive disorder in adults. Efficacy of duloxetine for the acute treatment of major depression has principally been established by 4 double-blind, placebo-controlled studies of weeks' duration in outpatient settings in adults. Efficacy of duloxetine for the maintenance treatment of major depressive disorder has been established in a randomized, placebo-controlled relapse prevention study in which adult outpatients who met DSM-IV criteria for major depressive disorder initially received duloxetine 60 mg once daily in a week, open-label acute phase. Patients who responded to treatment during the acute phase were then randomized to continue receiving duloxetine at the same dosage or to receive placebo for 26 weeks in the continuation phase. The duloxetine-treated patients experienced a longer time to relapse of depression compared with the placebo recipients. Antidepressant efficacy of duloxetine in hospital settings has not been adequately studied to date. Duloxetine hydrochloride is used for the acute management of generalized anxiety disorder in adults.
Duloxetine in the treatment of depression, anxiety disorder, and also used for managing pain caused by fibromyalgia and diabetic peripheral neuropathy DPNP. Increased risk of hepatic toxicity in patients with substantial alcohol use. Potentially Fatal: Avoid use with antiarrhythmics amiodarone, quinidine, antipsychotics chlorpromazine, TCAs fluoxetine, fluvoxamine, azole antifungals, quinolones ciprofloxacin, ciclosporin. Uncontrolled narrow-angle glaucoma. Concomitant use or within 2 wk of MAOIs.
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Journal Impact Factor: 1. This journal helps psychotherapists who are facing complexities and controversies along with the cutting edge aspects of Psychopathological Dysfunctions and Psychiatric Diagnosis. Such maladaptive behaviours prevent the individual from living a normal, healthy lifestyle. Dysfunctional behaviour is not always caused by a disorder it may be voluntary. It serves as reference for a range of professionals in the field of health and mental health.

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Government of Newfoundland and Labrador. Strength This refers to the amount of the active medicinal ingredient e. Benefit Status Open - Drugs which are reimbursed with no criteria or prior approval. Note: a drug may have limitations that restrict usage. Limitations Drugs which are restricted to those individuals who meet the defined restriction requirements. Limitation based on age such as children under 12 years of age.
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According to the WHO, clinical studies are currently conducted in Lebanon. Mechanism of action : Duloxetine is a combined serotonin 5-HT and noradrenaline NA reuptake inhibitor. It weakly inhibits dopamine reuptake with no significant affinity for histaminergic, dopaminergic, cholinergic and adrenergic costs cymbalta 60 mg. Duloxetine dose-dependently increases extracellular levels of serotonin and noradrenaline in various brain areas of animals. Pharmacodynamic effects : Duloxetine normalised pain thresholds in several preclinical models of neuropathic and inflammatory pain and attenuated pain behaviour in a model of persistent pain. The pain inhibitory action of duloxetine is believed to be a result of potentiation of descending inhibitory pain pathways within the central nervous system.
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This is not an anatomical barrier as such, rather a combination of the tight junctions between endothelial cells of brain capillaries and the close association of glial cells with the outside of the capillaries.
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