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Prevents the occurrence of epileptic seizures, allodynia and hyperalgesia, and especially the pain response in different models of neuropathic pain. In addition,it reduces the pain response to peripheral inflammation, but does not affect the immediate behavior caused by pain.

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Entry of contrast agent into the central nervous system is unlikely unless the integrity of the bloodbrain barrier has been compromised by the osmotic effects of the contrast agent. Dehydration of endothelial cells of brain capillaries may allow diffusion of contrast agent into the brain. If this happens, the contrast agent may provoke seizures. LOCAs are the safer contrast agents in this respect. There is a link between osmolality of iodine contrast media and the risk of renal toxicity.


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