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However, although these conditions are relatively rare, they are included here because the consequences of them affect skeletal muscle function and because health care professionals are likely to be involved in the care of patients with these two conditions.

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Moreover, like antiepileptic drugs, local anaesthetics show use dependence in that they preferentially block neurons that are transmitting impulses at high frequency (as pain sensory neurons do).

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Only about potential interactions clinically manifest themselves. Factors that determine those individuals who will show symptoms of drug interaction are unknown.

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